Targeted radiotherapy with Sm-153-EDTMP in nine cases of canine primary bone tumours

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Targeted radiotherapy with Sm-153-EDTMP in nine cases of canine primary bone tumours.

Nine dogs with primary bone tumours were treated with Samarium-153-EDTMP (Sm-153-EDTMP). Conventional treatment protocols were precluded by the size of the dogs and the owners' refusal of limb amputation. All the tumours were of the appendicular skeleton; 4 were confirmed osteosarcomas. The other 5 tumours were radiologically suspect for osteosarcoma. Bone scans were performed on all dogs using...

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Lu - DOTMP , 153 Sm - DOTMP , 175 Yb - EDTMP and 186 / 188 Re - CTMP : Novel Agents for Bone Pain Palliation and Their Comparison with 153 Sm - EDTMP

Designing ideal radiopharmaceuticals for use as bone pain palliatives require the use of a moderate energy β emitter with a stable carrier molecule. Cyclic polyaminophosphonate ligands are known to form complexes with higher thermodynamic stability and kinetic inertness. The present study therefore envisages the use of a few moderate energy β emitters, viz. Lu (T1/2 = 6.71 d, Eβmax= 497 keV), S...

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Clinical and clinicopathologic response of canine bone tumor patients to treatment with samarium-153-EDTMP.

Forty dogs with spontaneous skeletal neoplasia were treated with 153Sm-EDTMP (ethylenediaminetetramethylene phosphonic acid). Both primary and metastatic lesions were treated. Two treatment regimes, a single (37 MBq (1.0 mCi)/kg dose or two 37 MBq (1.0 mCi)/kg doses separated by 1 wk) were tested. Response to treatment was varied. Large lesions with minimal tumor bone formation responded poorly...

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Rare Cases of Primary Canine Extragenital Transmissible Venereal Tumours

A 41⁄2 months old female Boxer pup, 6 years old Dachshund bitch and 10 years old Labrador dog were presented with extragenital transmissible venereal tumors. Based on the anamnesis, clinical symptoms and cytological examinations the cases were diagnosed as primary extragenital transmissible venereal tumors and histopathological examination of the specimens confirmed the diagnosis. The animals w...

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Biodistribution of samarium-153-EDTMP in rats treated with docetaxel.

PURPOSE Many patients with metastatic bone disease have to use radiopharmaceuticals associated with chemotherapy to relieve bone pain. The aim of this study was to assess the influence of docetaxel on the biodistribution of samarium-153-EDTMP in bones and other organs of rats. METHODS Wistar male rats were randomly allocated into 2 groups of 6 rats each. The DS (docetaxel/samarium) group rece...

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ژورنال

عنوان ژورنال: Journal of the South African Veterinary Association

سال: 1998

ISSN: 2224-9435,1019-9128

DOI: 10.4102/jsava.v69i1.802